Duke vs. Clemson prediction, odds, spread, line, time: 2026 college basketball picks from proven model

Two of the Atlantic Coast Conference’s top teams clash when the No. 20 Clemson Tigers face the fourth-ranked Duke Blue Devils on Saturday. Clemson is coming off a 76-66 loss to Virginia Tech on Wednesday, while Duke rolled to a 70-54 win at Pittsburgh on Tuesday. The Tigers (20-5, 10-2 ACC), who are tied with Virginia for second in the conference, are 6-2 on the road this season. The Blue Devils (22-2, 11-1 ACC), who lead the ACC, are 11-0 on their home floor. 

Tipoff from the Cameron Indoor Stadium in Durham, N.C., is set for noon ET. Duke is a 13.5-point favorite in the latest Duke vs. Clemson odds from DraftKings Sportsbook, while the over/under for total points scored is 132.5. Before making any Clemson vs. Duke picks, check out the men’s college basketball predictions and betting advice from the SportsLine Projection Model.

New users can target the DraftKings promo code, which offers $300 in bonus bets if your $5+ bet wins:

The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 15 on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on an 11-5 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

Now, the model has simulated Clemson vs. Duke 10,000 times and just revealed its coveted men’s college basketball picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several men’s college basketball odds and men’s college basketball betting lines for Duke vs. Clemson:

New users can also target the latest Underdog promo code, good for $75 in fantasy bonus entries when you play $5 with the promo code CBSSPORTS2 in select states.

How to make Clemson vs. Duke picks

SportsLine’s model is going Over on the total (133.5 points). The Over has hit in five of the last 10 head-to-head meetings between the schools. The Over also hit in Clemson’s last game. 

The model projects the Tigers to have four players score 10.4 points or more, including Jestin Porter’s projected 12.2 points. The Blue Devils, meanwhile, are projected to have three players score 10.1 or more points, led by Cameron Boozer, who is projected to score 21.8 points. The Over clears in well over 80% of simulations. 

The model also says one side of the spread hits well over 50% of the time. You can only see that pick at SportsLine.

So who wins Duke vs. Clemson, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Clemson vs. Duke spread to back, all from the advanced model that has simulated this game 10,000 times, and find out.